abstract：:The retrograde response of HRP-labelled intercostal motoneurons was compared in adult (1-2 years) and aging (10-15 years) cats, 64-68 days following crush of intercostal nerves or following nerve transection with proximal ligation. A comparison of the neuroglial response to these two lesions was also made. In both adu...

journal_title：Neurobiology of aging

authors： Johnson IP,Sears TA,Hunter AS

更新日期：1991-03-01 00:00:00

abstract：:Several RNA sequences were tested for age-related changes in prevalence levels in the mouse cerebral cortex, hippocampus, and cerebellum. In all three regions, there were increased levels of RNA for glial fibrillary acidic protein, an astrocyte-specific protein, by RNA gel-blot analysis and by a solution hybridization...

journal_title：Neurobiology of aging

authors： Goss JR,Finch CE,Morgan DG

更新日期：1991-03-01 00:00:00

abstract：:Synaptic density in the medial and lateral septal nuclei was examined in 3 and 24-28 months of age Fischer 344 rats. The lateral nucleus had a higher synaptic density than the medial region in both age groups. There were no statistically significant differences in synapse density in either region as a function of age,...

journal_title：Neurobiology of aging

authors： Scheff SW,Scott SA,DeKosky ST

更新日期：1991-01-01 00:00:00

abstract：:Previous electrophysiological studies in aged rats have revealed a number of deficits in noradrenergic neurotransmission in the central nervous system. Such deficits include subsensitivity to the depressant effects of norepinephrine on cerebellar Purkinje neurons, which has been attributed specifically to altered beta...

journal_title：Neurobiology of aging

authors： Parfitt KD,Bickford-Wimer P

更新日期：1990-11-01 00:00:00

abstract：:Acetyl-1-carnitine (AC) was administered via drinking water for six months to one group (OLD-AC) of male F-344 rats beginning at 16 months of age, while another group (OLD-CON) of rats was given water only during that period. The rats were maintained on this treatment throughout behavioral testing, which began at 22 m...

journal_title：Neurobiology of aging

authors： Barnes CA,Markowska AL,Ingram DK,Kametani H,Spangler EL,Lemken VJ,Olton DS

更新日期：1990-09-01 00:00:00

abstract：:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

journal_title：Neurobiology of aging

authors： Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

更新日期：1990-07-01 00:00:00

abstract：:The release of endogenous and newly synthesized acetylcholine (ACh) was examined in neostriatal slices prepared from young adult (10-month) and aged (28-month) Fischer 344 rats. Both spontaneous and potassium-stimulated release were tested after various in vitro incubation times (1, 3 or 5 hr). The potassium-stimulate...

journal_title：Neurobiology of aging

authors： Weiler MH

更新日期：1990-07-01 00:00:00

abstract：:Aging of the nervous system is characterized by reduced anatomical plasticity. The cause of this decreased plasticity is not known because it is usually not possible to distinguish between extrinsic and intrinsic factors that affect neuronal growth. One example of age-related reduced neuronal plasticity that is amenda...

journal_title：Neurobiology of aging

authors： Crutcher KA

更新日期：1990-05-01 00:00:00

abstract：:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

journal_title：Neurobiology of aging

authors： Miranda R,Ceckler T,Guillet R,Kellogg CK

更新日期：1990-03-01 00:00:00

abstract：:Long-term ovariectomy attenuates several neuroendocrine-dependent changes in reproductive function of aging female rodents, but the sites affected and underlying mechanisms are not known. This study was designed to identify effects of aging on hypothalamic-preoptic neurocytoarchitecture and to determine whether long-t...

journal_title：Neurobiology of aging

authors： Miller MM,Gould BE,Nelson JF

更新日期：1989-11-01 00:00:00

abstract：:We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

journal_title：Neurobiology of aging

authors： Johnson SA,Rogers J,Finch CE

更新日期：1989-11-01 00:00:00

abstract：:Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretat...

journal_title：Neurobiology of aging

authors： Roses AD

更新日期：1989-09-01 00:00:00

abstract：:Support has recently been voiced for the genetic hypothesis of Alzheimer's disease; frequently at the expense of considerations of environmental factors. In the adult, genetic diseases rarely exist without modification by environment forces. Atherosclerosis leading to myocardial infarction may provide a useful model t...

journal_title：Neurobiology of aging

authors： Perl DP

更新日期：1989-09-01 00:00:00

abstract：:In attempts to understand the diverse roles which trophic activities exert in neuronal development and maintenance, it is useful to define some framework from within which to view their function. An example of such an outline is presented, sufficiently broad to avoid excluding by definition agents with clearly neurotr...

journal_title：Neurobiology of aging

authors： Haverkamp LJ

更新日期：1989-09-01 00:00:00

abstract：:While cytoskeletal abnormalities are prominent in the neurons of patients with Alzheimer's disease, the possibility remains that these changes are secondary to changes in the neuronal environment. The success of NGF in the therapy of Alzheimer's disease may be dependent on its ability to promote neuronal survival rath...

journal_title：Neurobiology of aging

authors： Shelanski ML

更新日期：1989-09-01 00:00:00

abstract：:Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered thr...

journal_title：Neurobiology of aging

authors： Hollister LE

更新日期：1989-09-01 00:00:00

abstract：:Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with ...

journal_title：Neurobiology of aging

authors： DeFeudis FV

更新日期：1989-09-01 00:00:00

abstract：:N-Methyl-D-Aspartate (NMDA) receptors are believed to play a critical role in excitotoxic cell death in the CNS. The distribution of NMDA-preferring binding sites is compared here with the patterns of selective neuronal death observed in Alzheimer's disease and following transient ischemia. The distribution of NMDA re...

journal_title：Neurobiology of aging

authors： Lee KS

更新日期：1989-09-01 00:00:00

abstract：:The review by Harbaugh describes new methods for delivering drugs to the diseases and damaged central nervous system. The potential of these methods, infusible pumps, implantable polymers, and neural transplants, is truly extraordinary. One can anticipate that many neurological disorders may be treated by these method...

journal_title：Neurobiology of aging

authors： Gash DM

更新日期：1989-09-01 00:00:00

abstract：:Etiologically heterogeneous subgroups of patients with Alzheimer's disease (AD) exist and need to be distinguished so as to better identify genetic causes of familial cases. Furthermore, the presence of AD neuropathology in Down syndrome (trisomy 21) subjects older than 35 years suggests that AD in some cases is cause...

journal_title：Neurobiology of aging

authors： Schapiro MB,Rapoport SI

更新日期：1989-09-01 00:00:00

abstract：:The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decrease...

journal_title：Neurobiology of aging

authors： Lal S,Nair NP,Thavundayil JX,Tawar V,Tesfaye Y,Dastoor D,Gauthier S,Guyda H

更新日期：1989-05-01 00:00:00

abstract：:An age-related phosphorylation of the 200kD neurofilament protein (NF200) has been observed in the axons of cerebellar basket cells of normal human fixed brain tissue from individuals older than 60 years, but not in younger individuals. The probe for this study was the monoclonal antibody SMI-34 which detects a phosph...

journal_title：Neurobiology of aging

authors： Blanchard BJ,Ingram VM

更新日期：1989-05-01 00:00:00

abstract：:Eight elderly subjects (aged 68-95 years) and 6 young adults (aged 21-24 years) performed elbow flexion and extension movements in a visual step-tracking paradigm. Movement amplitudes ranging from 10 degrees-80 degrees were made under two instructions: "move at own speed" and "move fast and accurate." In a second expe...

journal_title：Neurobiology of aging

authors： Darling WG,Cooke JD,Brown SH

更新日期：1989-03-01 00:00:00

abstract：:The present study assessed whether there are age-dependent differences in up-regulation of opiate receptors following chronic naloxone treatment in mature (3 months) and aged (27 months) male Wistar rats. Half of each age group were implanted subdermally with slow-release naloxone pellets for 10 days, and half were gi...

journal_title：Neurobiology of aging

authors： Neisewander JL,Nonneman AJ,McDougall SA,Bardo MT

更新日期：1989-01-01 00:00:00

abstract：:After a decade of intense study of cholinergic therapies for Alzheimer's disease, three conditions in this field are apparent: 1) The potential that cholinergic agents will ameliorate the memory dysfunction of Alzheimer patients (as 1-dopa benefits Parkinson patients) is still a stimulus for research. 2) Cholinergic n...

journal_title：Neurobiology of aging

authors： Ashford JW,Sherman KA,Kumar V

更新日期：1989-01-01 00:00:00

abstract：:The goal of this experiment was to determine the correlations among different behavioral and neurobiological measures in aged rats. Aged Sprague-Dawley rats were given a battery of cognitive and sensorimotor tests, followed by electrophysiological assessment of sleep and biochemical measurements of various neurotransm...

journal_title：Neurobiology of aging

authors： Markowska AL,Stone WS,Ingram DK,Reynolds J,Gold PE,Conti LH,Pontecorvo MJ,Wenk GL,Olton DS

更新日期：1989-01-01 00:00:00

abstract：:Dementia is believed to result from the loss of selective neurons within the brain, but approaches for systematic study of that degenerative process are hampered by the complexity of the neuronal milieu. Tissue culture models provide a means to reduce dramatically the variables inherent in the study of neuronal plasti...

journal_title：Neurobiology of aging

authors： Azmitia EC,Whitaker-Azmitia PM,Bartus R

更新日期：1988-09-01 00:00:00

abstract：:This commentary addresses issues raised in common by the various authors of papers in this section: the role of different chemical systems in memory, new approaches for assessing the effects of drugs, and issues for the future in evaluating animal models of human disorders of memory. ...

journal_title：Neurobiology of aging

authors： Whitehouse PJ

更新日期：1988-09-01 00:00:00

abstract：:The three chapters on the use of classical conditioning paradigms to investigate neurobiological and behavioral substrates of memory impairments with aging are in close agreement on all key issues. Based on these chapters, it is argued here that classical conditioning of discrete behavioral responses in rabbit and oth...

journal_title：Neurobiology of aging

authors： Thompson RF

更新日期：1988-09-01 00:00:00

abstract：:The neurobiology of aging continues to attract scientists and techniques from the more fundamental disciplines, as witness the great strides now being made from molecular genetic approaches to Alzheimer's disease. The present report is a commentary on reviews of immune mechanisms and tissue culture methods applied to ...

journal_title：Neurobiology of aging

authors： Rogers J,Rovigatti U

更新日期：1988-09-01 00:00:00

abstract：:This paper reports a series of experiments that assessed learning and memory performance in aged rats from a neuropsychological perspective. Relative to young adults, old rats displayed rapid rates of forgetting, increased susceptibility to interference, and poor long-term recall of specific experiences. There were no...

journal_title：Neurobiology of aging

authors： Winocur G

更新日期：1988-09-01 00:00:00

abstract：:In this review the relationship between the basal forebrain cholinergic system and memory is explored. It appears that different components of the cholinergic forebrain system [e.g., medial septum (MS) and nucleus basalis magnocellularis (NBM)] have dissociable mnemonic functions in animals, and comparable mnemonic fu...

journal_title：Neurobiology of aging

authors： Kesner RP

更新日期：1988-09-01 00:00:00

abstract：:Using a dosing paradigm and an automated behavioral testing procedure designed to maximize potential drug efficacy, we evaluated the ability of clonidine to improve performance of aged monkeys on a trial-specific memory task. These results indicated that neither acutely administered (0.0025-0.04 mg/kg) or subchronical...

journal_title：Neurobiology of aging

authors： Bartus RT,Dean RL

更新日期：1988-07-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:The central biochemical pathology of anorexia and the natural aging of the brain is similar. Biochemical models for drug withdrawal and depression may also assist in understanding geriatric anorexia. Norepinephrine, corticotropin releasing factor and beta-endorphin may key neurotransmitters in all of these conditions....

journal_title：Neurobiology of aging

authors： Giannini AJ

更新日期：1988-01-01 00:00:00

abstract：:A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular ...

journal_title：Neurobiology of aging

authors： Scheibel AB,Duong T

更新日期：1988-01-01 00:00:00

abstract：:Perhaps cognitive and brain imaging measures have been pushed almost as far as they can go in helping diagnose or understand AD. Their value may increase with the development of better models of the disease and the addition of new types of measurements to the armamentarium (e.g., eye-tracking, olfactory, and dermatogl...

journal_title：Neurobiology of aging

authors： Roberts E

更新日期：1988-01-01 00:00:00

abstract：:Alzheimer's disease of early onset versus that of late onset represent different syndromes, with distinct neuropathologies. Patients with early onset disease exhibit a more severe and more widespread loss of neurons from cortical and sub-cortical regions and the neurochemical changes involve not only the cholinergic s...

journal_title：Neurobiology of aging

authors： Iversen LL

更新日期：1987-11-01 00:00:00

abstract：:Behavioral profiles of young (3-6 months) and aged (24-27 months) rats were compared in three respects: (1) short-term memory, (2) exploration and (3) locomotor activity. Compared to young rats, aged rats were impaired in the 8-arm radial maze acquisition, but not in the delayed reinforced alternation acquisition. The...

journal_title：Neurobiology of aging

authors： Willig F,Palacios A,Monmaur P,M'Harzi M,Laurent J,Delacour J

更新日期：1987-09-01 00:00:00

abstract：:Based on evidence that high Mg2+ counteracts age-related declines in synaptic plasticity, and that aged rat hippocampal neurons exhibit prolonged Ca2+-dependent K+ currents, it is proposed that an underlying cause of altered Ca2+ homeostasis during brain aging may be an increased membrane conductance to Ca2+. An appar...

journal_title：Neurobiology of aging

authors： Landfield PW

更新日期：1987-07-01 00:00:00